Macromolecular synthesis following a single application of alkylating agents used as initiators of mouse skin tumorigenesis.
نویسندگان
چکیده
sultone was observed at 2 days. Urethan depressed DNA synthesis for 24 hr without a subsequent increase and without detectable epidermal hyperplasia. Chloromethyl methyl ether. a weak or inactive initiating agent, produced no change in macromolecular synthesis, and the skin sections appeared normal. When either j3-propiolactone or urethan was applied to mouse skin in which DNA synthesis had been prestimulated with a noncarcinogenic irritant, these agents blocked DNA synthesis.
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عنوان ژورنال:
- Cancer research
دوره 33 4 شماره
صفحات -
تاریخ انتشار 1973